Clinical Evidence

A selection of clinical studies establishing the effectiveness of our medical grade silicone solutions for scar management:

Efficacy of silicone gel for treating hypertrophic scars and keloids

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918339/

J Cutaneous Aesthet Surg. 2009 July-Dec; 2(2): 104–106.

  • “Arguably, only two treatments have sufficient evidence for scar management; local application of silicone gel sheeting and intralesional injection of corticosteroids. The former is generally indicated as both a preventive and a therapeutic device, the latter only as a therapeutic agent. Topical silicone gel sheeting is cumbersome to keep on the scar, and patient compliance is often low for lesions in visible areas.”
  • “Topical silicone gel is a safe and effective treatment for hypertrophic and keloid scars. It is easy to apply and cosmetically acceptable.”

Use of silicone adhesives to reduce scars

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486716/

Adv Wound Care (New Rochelle). July 1, 2015; 4(7): 422–430

  • "...concluded that clinical trials, which were used to evaluate silicone gel for the treatment of hypertrophic and keloid scars, demonstrate that there are improvements in scar thickness and scar color."
  • “The clinical support of topical silicone gel products against all alternative scar therapies is what has maintained its position as the internationally recommended first-line form of scar management favored by the consensus of healthcare professionals. Although steroid injections offer a significant positive impact on scarring, they remain a supportive treatment, in part, because of the associated expense and impracticality. Other existing treatments such as topical creams/gels and dressings containing active additives such as onion extract, vitamins C and E and moisturizing agents are often seen to provide little or no additional benefit over SGS itself.”

Review of silicone gel sheets and silicone gel for the prevention of hypertrophic scars and keloids

https://pubmed.ncbi.nlm.nih.gov/28570253/

2017 May;29(5):154-158.

  • "There was statistical significance in the effectiveness of silicone gel and silicone gel sheets in preventing keloids or hypertrophic scars, particularly in wounds with skin lesions."

A prospective randomized double-blind trial of silicone gel plus plant extracts versus placebo in the prevention and improvement of pre-sternal hypertrophic scars. [2020]

https://www.cell.com/heliyon/pdf/S2405-8440(20)30728-3.pdf

  • "...the study showed that silicone gel plus herbal extract gel could improve scar relief in height (p ¼ 0.005) and flexibility (p < 0.001) compared to placebo."

Randomized controlled clinical trial of topical silicone gel in post-lower segment cesarean closure scar in Primigravida

https://link.springer.com/article/10.1007/s12262-020-02420-7 

Indian Journal of Surgery vol 83 , the pages 526–530 (2021)

  • “Topical silicone gel was superior in reducing overall scar quality at 1 month and 3 months. Topical silicone gel was a superior product for the initial management of cesarean scars.”

"Prominent scar therapy: glide applicator versus traditional topical polydimethylsilicone sheets for reduction of hypertrophic scars and keloids".

- PLASTIC SURGERY AESTHETIC CENTER

"The Mederma Myth: Fading Out of Sight—New Advances to Minimize Surgical Scars."

- AMERICAN ACADEMY OF DERMATOLOGY

"Silicone gel sheets for the prevention and management of hypertrophic scars and evolving keloids"

-JAMES E. FULTON, JR, MD, PHD

"Silicone Gel Sheets in Scar Therapy"

- BRUCE E. KATZ, MD, NEW YORK, NEW YORK